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Curr Opin Pharmacol. 2011 Feb;11(1):29-33. doi: 10.1016/j.coph.2011.02.004. Epub 2011 Mar 8.

5-HT and the immune system.

Author information

1
Department of Pharmacology, Georgetown University, 3900 Reservoir Rd NW, Washington, DC 20007, United States. gpa3@georgetown.edu

Abstract

The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.

PMID:
21393060
PMCID:
PMC3144148
DOI:
10.1016/j.coph.2011.02.004
[Indexed for MEDLINE]
Free PMC Article

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