Format

Send to

Choose Destination
J Infect Dev Ctries. 2011 Mar 2;5(2):119-22.

Serotypes and antibiotic susceptibility of Streptococcus pneumoniae isolates causative of invasive diseases in Mexican children.

Author information

1
Instituto Nacional de Pediatría, Mexico City, Mexico.

Abstract

INTRODUCTION:

Streptococcus pneumoniae is a worldwide leading cause of morbidity and mortality, while susceptibility towards penicillin and macrolides can be less than 50% in many regions.

METHODOLOGY:

A total of 150 isolates of S. pneumoniae causative of invasive diseases in children were characterized, of which 24.6% had a fatal outcome.

RESULTS:

The most prevalent serotypes were 19F, 6B, 23F and 14. Resistance to penicillin, erythromycin (mostly of macrolide-lincosamide-streptogramin resistance phenotype) or trimethoprim-sulfamethoxazole was found in more than 40% of the isolates, but no resistance phenotype appeared linked to lethality. Serotype 3 isolates, which were seldom resistant, had a twofold lethality rate compared to the total sample.

CONCLUSION:

Serotyping could provide a better outcome-predicting tool than susceptibility testing. The seven-valent vaccine does not include the most prevalent serotypes found in Mexico.

PMID:
21389591
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for The Journal of Infection in Developing Countries
Loading ...
Support Center