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Trends Biochem Sci. 2011 May;36(5):245-53. doi: 10.1016/j.tibs.2011.01.003. Epub 2011 Mar 8.

DHHC palmitoyl transferases: substrate interactions and (patho)physiology.

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Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.


S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.

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