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J Nat Prod. 2011 Apr 25;74(4):670-4. doi: 10.1021/np100727h. Epub 2011 Mar 9.

Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp.

Author information

1
Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp

Abstract

A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of 1 were elucidated by interpretation of NMR and other spectroscopic data, and the absolute configuration was determined using the modified Mosher method. Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria.

PMID:
21388191
DOI:
10.1021/np100727h
[Indexed for MEDLINE]

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