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Dtsch Med Wochenschr. 2011 Mar;136(11):541-5. doi: 10.1055/s-0031-1274539. Epub 2011 Mar 8.

[Central nervous system control of energy homeostasis].

[Article in German]

Author information

1
Medizinische Klinik 1, Universitätsklinikum Schleswig-Holstein, Campus Lübeck.

Abstract

The brain is continuously supplied with information about the distribution and amount of energy stores from the body periphery. Endocrine, autonomic and cognitive-hedonic signals are centrally integrated and exert effects on the whole organism via anabolic and catabolic pathways. The adiposity signals insulin and leptin reflect the amount of body fat and are part of a negative feedback mechanism between the periphery and the central nervous system. The hypothalamic arcuate nucleus is the most important central nervous structure, which integrates this information. Furthermore, the CNS is able to directly measure and to respond to changes in the concentration of certain nutrients. In order to develop effective therapies for the treatment of disorders of energy balance the further elucidation of these neuro-biological processes is of crucial importance. This article provides an overview of the CNS regulation of metabolism and its underlying molecular mechanisms.

PMID:
21387213
DOI:
10.1055/s-0031-1274539
[Indexed for MEDLINE]

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