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Int J Obes (Lond). 2011 Dec;35(12):1455-65. doi: 10.1038/ijo.2011.56. Epub 2011 Mar 8.

Altered hypothalamic function in diet-induced obesity.

Author information

1
Laboratory of Cell Signaling, University of Campinas, Campinas, São Paulo, Brazil. lavelloso.unicamp@gmail.com

Abstract

Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure.

PMID:
21386802
PMCID:
PMC3383790
DOI:
10.1038/ijo.2011.56
[Indexed for MEDLINE]
Free PMC Article

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