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Genetics. 2011 May;188(1):235-7. doi: 10.1534/genetics.111.127209. Epub 2011 Mar 8.

Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants.

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1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Gene knockdown by RNA interference (RNAi) in Caenorhabditis elegans is readily achieved by feeding bacteria expressing double-stranded RNA (dsRNA). Enhanced RNAi (Eri) mutants facilitate RNAi due to their hypersensitivity to dsRNA. Here, we compare eight Eri mutants for sensitivity to ingested dsRNA, targeting a variety of tissue-specific genes.

PMID:
21385728
PMCID:
PMC3120140
DOI:
10.1534/genetics.111.127209
[Indexed for MEDLINE]
Free PMC Article
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