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Clin Exp Rheumatol. 2011 Jan-Feb;29(1 Suppl 64):S35-9. Epub 2011 May 11.

Orbital mass as manifestation of Wegener's granulomatosis: an ophthalmologic diagnostic approach.

Author information

1
Department of Ophthalmology, University Medical Center Utrecht, the Netherlands. w.r.bijlsma@umcutrecht.nl

Abstract

OBJECTIVES:

Orbital manifestation of Wegener's granulomatosis is diverse and diagnosis is often difficult. This study aims to improve the diagnostic strategy in orbital Wegener.

METHODS:

A review of the diagnostic process in patients in whom a diagnosis of orbital WG was considered.

RESULTS:

Thirty-three patients were analysed, consisting of 15 patients with orbital WG, 11 with idiopathic orbital inflammation, 6 with orbital sarcoidosis and one with aspergillosis. Diagnostic findings indicating orbital WG were ear/nose/throat involvement, multiple organ system involvement, a positive ANCA, and on histology vasculitis, whereas granulomatous inflammation without signs of vasculitis was more indicative of another orbital disease.

CONCLUSIONS:

The diagnostic process of orbital WG should include CT scanning of the orbit and sinuses, ANCA blood testing, consultation of a rheumatologist, an ophthalmologist, and an ear-nose-throat specialist, and biopsy of an easily accessible, active inflammatory lesion.

PMID:
21385547
[Indexed for MEDLINE]

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