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Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):441-8. doi: 10.1002/bdra.20785. Epub 2011 Mar 7.

BMP signaling in congenital heart disease: new developments and future directions.

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1
Institute of Biosciences and Technology, Texas A&M System Health Science Center, 2121 W. Holcombe Blvd., Houston, TX 77030, USA.

Abstract

Congenital heart malformations are the most common of all congenital human birth anomalies. During the past decade, research with zebrafish, chick, and mouse models have elucidated many fundamental genetic pathways that govern early cardiac patterning and differentiation. This review highlights the roles of the bone morphogenetic protein (BMP) signaling pathway in cardiogenesis and how defective BMP signals can disrupt the intricate steps of cardiac formation and cause congenital heart defects.

PMID:
21384533
PMCID:
PMC3124406
DOI:
10.1002/bdra.20785
[Indexed for MEDLINE]
Free PMC Article
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