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Nat Rev Microbiol. 2011 Apr;9(4):291-306. doi: 10.1038/nrmicro2539. Epub 2011 Mar 8.

Modulation of NF-κB signalling by microbial pathogens.

Author information

1
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100266, Gainesville, Florida, USA.

Abstract

The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host response to infection by microbial pathogens, by orchestrating the innate and acquired host immune responses. The NF-κB proteins are activated by diverse signalling pathways that originate from many different cellular receptors and sensors. Many successful pathogens have acquired sophisticated mechanisms to regulate the NF-κB signalling pathways by deploying subversive proteins or hijacking the host signalling molecules. Here, we describe the mechanisms by which viruses and bacteria micromanage the host NF-κB signalling circuitry to favour the continued survival of the pathogen.

PMID:
21383764
PMCID:
PMC3611960
DOI:
10.1038/nrmicro2539
[Indexed for MEDLINE]
Free PMC Article

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