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J Cell Biol. 2011 Mar 7;192(5):723-33. doi: 10.1083/jcb.201010058.

Principles of chromosomal organization: lessons from yeast.

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1
Groupe Imagerie et Modélisation, Département Biologie Cellulaire et Infection, Institut Pasteur, F-75015 Paris, France.

Abstract

The spatial organization of genes and chromosomes plays an important role in the regulation of several DNA processes. However, the principles and forces underlying this nonrandom organization are mostly unknown. Despite its small dimension, and thanks to new imaging and biochemical techniques, studies of the budding yeast nucleus have led to significant insights into chromosome arrangement and dynamics. The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order.

PMID:
21383075
PMCID:
PMC3051815
DOI:
10.1083/jcb.201010058
[Indexed for MEDLINE]
Free PMC Article
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