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Bioorg Med Chem. 2011 Apr 1;19(7):2418-27. doi: 10.1016/j.bmc.2011.02.010. Epub 2011 Feb 18.

Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1.

Author information

1
Department of Organic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Abstract

Eleven novel sialidase inhibitors 9 and 10 with an N-sulfonylamidino group at the C-4 position of Neu5Ac2en 1 against human parainfluenza virus type 1 (hPIV-1) were synthesized using copper-catalyzed three-component coupling reactions, and their inhibitory activities against hPIV-1 sialidase were studied.

PMID:
21382718
DOI:
10.1016/j.bmc.2011.02.010
[Indexed for MEDLINE]

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