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Clin Biochem. 2011 Jun;44(8-9):618-22. doi: 10.1016/j.clinbiochem.2011.02.013. Epub 2011 Mar 4.

Heritability of genetic variants of resistin gene in patients with coronary artery disease: a family-based study.

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1
Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.

Abstract

OBJECTIVE:

The resistin gene (RETN) -420C>G and +299G>A polymorphism was investigated in a case-control study from forty complex Pakistani families with coronary artery disease (CAD) history. Heritability of the susceptible/variant alleles was investigated from parent-offspring trios in these families.

METHOD:

Resistin levels were determined from 239 individuals by enzyme-linked immunosorbent assay. Genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism.

RESULTS:

Elevated resistin levels were observed from CAD cases vs. controls (p<0.0001). The RETN -420C>G and +299G>A polymorphism was more prevalent in cases vs. controls (p<0.0001). The transmission disequilibrium test revealed a significant association of the -420 and +299 polymorphism with CAD (χ(2)=34.4, p<0.0001 and χ(2)=31.6, p<0.0001, respectively).

CONCLUSION:

Elevated resistin, and the RETN -420C>G and +299G>A polymorphism may contribute to familial CAD. The -420 and +299 variant alleles are transmitted more frequently from parent to affected offspring. This is the first report on the association of the RETN +299G>A polymorphism with CAD.

[Indexed for MEDLINE]

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