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Nanoscale. 2011 May;3(5):1957-62. doi: 10.1039/c1nr00002k. Epub 2011 Mar 7.

Synthetic pathways to make nanoparticles fluorescent.

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1
Institute of Inorganic Chemistry, University of Duisburg-Essen, Campus Essen and Center for Nanointegration Duisburg-Essen (CeNIDE), Universitaetsstr. 5-7, 45117 Essen, Germany.

Abstract

In biosciences, it is often necessary to follow the pathway of nanoparticles within cells or tissues. The nanoparticles can be used as labeled sensors which may, e.g., address functionalities within a cell, carry other specific agents like drugs or be magnetic for tumor thermotherapy. In the context of nanotoxicology, the fate of a given nanoparticle is of interest. As many methods in cell biology are based on fluorescence detection, there is a strong demand to make nanoparticles fluorescent. Different ways to introduce fluorescence are reviewed and exemplified with typical kinds of nanoparticles, i.e. polymers, silica and calcium phosphate.

PMID:
21380471
DOI:
10.1039/c1nr00002k
[Indexed for MEDLINE]
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