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PLoS Pathog. 2011 Feb;7(2):e1001293. doi: 10.1371/journal.ppat.1001293. Epub 2011 Feb 17.

Genital tract sequestration of SIV following acute infection.

Author information

1
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. jwhitne2@bidmc.harvard.edu

Abstract

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

PMID:
21379569
PMCID:
PMC3040679
DOI:
10.1371/journal.ppat.1001293
[Indexed for MEDLINE]
Free PMC Article

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