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Nat Methods. 2011 Apr;8(4):315-7. doi: 10.1038/nmeth.1580. Epub 2011 Mar 6.

A bioinformatic assay for pluripotency in human cells.

Author information

1
Zentrum für Integrative Psychiatrie, Kiel, Germany. fj.mueller@zip-kiel.de

Abstract

Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles.

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PMID:
21378979
PMCID:
PMC3265323
DOI:
10.1038/nmeth.1580
[Indexed for MEDLINE]
Free PMC Article

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