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Fertil Steril. 2011 May;95(6):1966-9. doi: 10.1016/j.fertnstert.2011.02.015. Epub 2011 Mar 5.

Frozen-thawed blastocyst transfer reduces ectopic pregnancy risk: an analysis of single embryo transfer cycles in Japan.

Author information

1
Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Saitama, Japan. osamishr@saitama-med.ac.jp

Abstract

OBJECTIVE:

To evaluate the effect of frozen-thawed blastocyst transfer on ectopic pregnancy (EP) rate.

DESIGN:

Retrospective analysis.

SETTING:

Japanese registry of assisted reproductive medicine.

PATIENT(S):

Women who were registered during 2008.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Rates of live birth, EP, and spontaneous abortion in single blastocyst and cleavage-stage ET cycles in both fresh and frozen-thawed were determined.

RESULT(S):

In the frozen-thawed single blastocyst transfer cycles, 84 EPs of 10,312 clinical pregnancies (0.81%) were reported. There were 25 EPs of 1,361 clinical pregnancies (1.8%) in fresh IVF single blastocyst transfer cycles and 19 of 1,352 (1.4%) in fresh intracytoplasmic sperm injection single blastocyst transfer cycles. The rate of EPs after frozen-thawed single blastocyst transfers varied between 0.56% and 0.97% after stratification by age group.

CONCLUSION(S):

Frozen-thawed blastocyst transfers have reduced EP rates significantly compared with fresh blastocyst transfers.

[Indexed for MEDLINE]

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