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FEBS Lett. 2011 May 20;585(10):1393-9. doi: 10.1016/j.febslet.2011.02.038. Epub 2011 Mar 3.

Kinases and phosphatases in the mammalian circadian clock.

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Laboratory of Chronobiology, Charité Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany.


Posttranslational modifications of circadian oscillator components are crucial for the generation of circadian rhythms. Among those phosphorylation plays key roles ranging from regulating degradation, complex formation, subcellular localization and activity. Although most of the known clock proteins are phosphoproteins in vivo, a comprehensive view about the regulation of clock protein phosphorylation is still missing. Here, we review our current knowledge about the role of clock protein phosphorylation and its regulation by kinases and phosphatases in eukaryotes with a major focus on the mammalian circadian clock.

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