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Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. doi: 10.1016/j.bmcl.2011.02.036. Epub 2011 Feb 13.

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

Author information

1
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

Abstract

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.

PMID:
21376588
DOI:
10.1016/j.bmcl.2011.02.036
[Indexed for MEDLINE]

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