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Clin Nutr. 2011 Aug;30(4):490-3. doi: 10.1016/j.clnu.2011.01.013. Epub 2011 Mar 3.

The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial.

Author information

1
Cardiovascular Risk and Nutrition, Cardiovascular Epidemiology and Genetics, and Human Pharmacology and Clinical Neurosciences Research Groups, Research Institute Hospital del Mar (IMIM), Barcelona 08003, Spain.

Abstract

BACKGROUND & AIM:

Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation.

METHODS:

In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content.

RESULTS:

Plasma OLAB concentration was inversely associated with oxLDL (p < 0.001). Olive oil phenolic content increased OLAB generation, with the effect being stronger at higher concentrations of oxLDL (p = 0.020 for interaction). A direct relationship was observed between OLAB and the total olive oil phenol content in LDL (r = 0.209; p = 0.014). OLAB concentrations, adjusted for oxLDL, increased directly in a dose-dependent manner with the polyphenol content of the olive oil administered (p = 0.023).

CONCLUSION:

Olive oil polyphenols promote OLAB generation. This effect is stronger at higher concentrations of lipid oxidative damage.

PMID:
21376434
DOI:
10.1016/j.clnu.2011.01.013
[Indexed for MEDLINE]

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