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Fertil Steril. 2011 May;95(6):1922-7, 1927.e1. doi: 10.1016/j.fertnstert.2011.02.002. Epub 2011 Mar 3.

Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study.

Author information

1
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. daniel.green@stjude.org

Abstract

OBJECTIVE:

To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy.

DESIGN:

Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers.

SETTING:

Self-administered questionnaire.

PATIENT(S):

A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (≤0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Self-reported pregnancy events.

RESULT(S):

As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97-1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses≥22 Gy compared with those CCS receiving no HPT RT.

CONCLUSION(S):

These results support the hypothesis that exposures of 22-27 Gy HPT RT may be a contributing factor to infertility among female CCS.

PMID:
21376314
PMCID:
PMC3080448
DOI:
10.1016/j.fertnstert.2011.02.002
[Indexed for MEDLINE]
Free PMC Article

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