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Cell. 2011 Mar 4;144(5):640-2. doi: 10.1016/j.cell.2011.02.029.

The ribosome and TORC2: collaborators for cell growth.

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Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0815, USA.


The target of rapamycin complex 2 (TORC2) is a key regulator of cell growth. Zinzalla et al. (2011) now provide evidence that TORC2 is activated by direct association with the ribosome, which may ensure that TORC2 activity is calibrated to match the cell's intrinsic growth capacity.

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