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FEBS J. 2011 Jun;278(11):1808-17. doi: 10.1111/j.1742-4658.2011.08082.x. Epub 2011 Apr 7.

Natriuretic peptide metabolism, clearance and degradation.

Author information

1
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA. potter@umn.edu

Abstract

Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C.

PMID:
21375692
PMCID:
PMC4495883
DOI:
10.1111/j.1742-4658.2011.08082.x
[Indexed for MEDLINE]
Free PMC Article
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