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Br J Dermatol. 2011 Mar;164(3):660-4. doi: 10.1111/j.1365-2133.2011.10237.x.

A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.

Author information

1
Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK. Richard.warren@manchester.ac.uk

Abstract

BACKGROUND:

Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression.

OBJECTIVES:

The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis.

METHODS:

Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom(®) MassArray™ iPLEX Gold platform.

RESULTS:

We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4)) region.

CONCLUSIONS:

The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases.

[Indexed for MEDLINE]

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