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Br J Dermatol. 2011 Mar;164(3):660-4. doi: 10.1111/j.1365-2133.2011.10237.x.

A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.

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Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK.



Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression.


The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis.


Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom(®) MassArray™ iPLEX Gold platform.


We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4)) region.


The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases.

[Indexed for MEDLINE]

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