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Eur Rev Med Pharmacol Sci. 2010 Dec;14(12):1011-4.

Protective role of Pleurotus porrigens (Angel's wings) against gentamicin-induced nephrotoxicty in mice.

Author information

1
Department of Biology, University of Mazandaran, Babolsar, Iran.

Abstract

OBJECTIVES:

This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel's wings on gentamicin (GM)-induced nephrotoxicity.

MATERIAL AND METHODS:

Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatinine, serum urea, and blood urea nitrogen after the 10 consecutive days of treatment.

RESULTS:

Results show that GM-induced nephrotoxic animal model was successfully prepared. Methanolic fraction of Angel's wings attenuated the gentamicin-induced increase in level of serum creatinine, serum urea, and blood urea nitrogen.

CONCLUSIONS:

The present study shows that the extract at the doses 200 and 400 mg/kg, intraperitoneally offered significant nephroprotective action that is comparable with control group.

PMID:
21375131
[Indexed for MEDLINE]

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