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Inflamm Res. 2011 Jul;60(7):665-72. doi: 10.1007/s00011-011-0320-y. Epub 2011 Mar 4.

Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats.

Author information

1
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, Lubbock, TX 79430-9097, USA. leslie.shen@ttuhsc.edu

Abstract

OBJECTIVE:

Green tea proposes anti-inflammatory properties which may attenuate chronic inflammation-induced fibrosis of vessels. This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation.

TREATMENTS:

Forty 3-month-old female rats were assigned to a 2 (placebo vs. lipopolysaccharide, administration) × 2 (no GTP vs. 0.5% GTP in drinking water) factorial design for 12 weeks.

METHODS:

Masson's trichrome staining evaluated myocardial fibrosis in coronary vessels and surrounding myocardium. Whole blood specimens were counted for differentials. Spleen tumor necrosis factor-α (TNF-α) mRNA expression was determined by real-time RT-PCR. Data were analyzed by two-way analysis of variance (ANOVA) followed by mean separation procedures.

RESULTS:

After 12 weeks, lipopolysaccharide administration induced myocardial fibrosis in vessels and surrounding myocardium, spleen TNF-α mRNA expression, and leukocytes, while GTP supplementation in drinking water significantly averted such observation.

CONCLUSIONS:

GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses.

PMID:
21373880
DOI:
10.1007/s00011-011-0320-y
[Indexed for MEDLINE]
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