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Front Hum Neurosci. 2011 Feb 18;5:19. doi: 10.3389/fnhum.2011.00019. eCollection 2011.

Microstructural Parcellation of the Human Cerebral Cortex - From Brodmann's Post-Mortem Map to in vivo Mapping with High-Field Magnetic Resonance Imaging.

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Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.


The year 2009 marked the 100th anniversary of the publication of the famous brain map of Korbinian Brodmann. Although a "classic" guide to microanatomical parcellation of the cerebral cortex, it is - from today's state-of-the-art neuroimaging perspective - problematic to use Brodmann's map as a structural guide to functional units in the cortex. In this article we discuss some of the reasons, especially the problematic compatibility of the "post-mortem world" of microstructural brain maps with the "in vivo world" of neuroimaging. We conclude with some prospects for the future of in vivo structural brain mapping: a new approach which has the enormous potential to make direct correlations between microstructure and function in living human brains: "in vivo Brodmann mapping" with high-field magnetic resonance imaging.


brain map; cortical areas; cytoarchitecture; myeloarchitecture; quantitative T1 map

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