Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cardiovasc Nurs. 2011 Sep-Oct;26(5):423-9. doi: 10.1097/JCN.0b013e3182076a81.

The role of serotonin in depression and clotting in the coronary artery disease population.

Author information

1
School of Nursing, University of Texas Health Science Center at Houston, 6901 Bertner Avenue, Houston, TX 77030, USA. jennifer.e.sanner@uth.tmc.edu

Abstract

BACKGROUND:

Despite the strong evidence that depression is an independent risk factor for coronary artery disease (CAD), the underlying physiological mechanisms linking depression and CAD remain poorly understood.

OBJECTIVE:

This review of the literature focuses on the current understanding of the physiological effects of serotonin on depression and clotting as well as its role in CAD.

METHODS:

Articles for this review were identified using CINAHL, PsychINFO, and MEDLINE searches.

RESULTS:

Results revealed that depression is an independent risk factor for CAD. Although the physiological mechanisms underlying depression and related increases in acute coronary events remain unclear, serotonin plays an important role in depression and CAD. Elevated platelet serotonin levels promote clotting, which may be a potential underlying mechanism linking depression with CAD.

CONCLUSIONS:

This review of the literature suggests that elevated platelet serotonin levels may be associated with depression and the occurrence of major adverse coronary events. Future research should investigate if platelet serotonin levels contribute at least in part to the acute coronary events seen in patients with CAD who have elevated levels of platelet serotonin when depressed.

PMID:
21372736
DOI:
10.1097/JCN.0b013e3182076a81
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center