Send to

Choose Destination
Circ Res. 2011 Mar 4;108(5):619-28. doi: 10.1161/CIRCRESAHA.110.224519.

Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers.

Author information

Department of Cardiology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA.

Erratum in

  • Circ Res. 2011 Apr 15;108(8):e11.


Although important advances have been made in curing childhood cancer in the last several decades, long-term survivors face considerable morbidity and mortality because of late effects from their initial anticancer therapy. By 30 years after treatment, the cumulative mortality from treatment-related medical illness actually exceeds that of mortality from cancer recurrence. Cardiovascular disease, in particular, is a leading threat to the well-being of adult survivors of childhood cancers. Unfortunately, the mechanisms of these late cardiac effects are understudied and poorly understood. This article reviews cardiotoxicity associated with 2 major anticancer regimens used in treating childhood cancer patients: anthracycline treatment and radiation therapy. The known pathophysiology and clinical cardiac risk factors that further predispose these patients to late-onset cardiac events are discussed. Basic and translational research is urgently needed to clarify pathophysiologic mechanisms of late cardiac effects and to develop therapies to improve both long-term survival and quality of life of adults cured of pediatric cancers.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center