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J Biol Chem. 2011 Apr 22;286(16):13801-4. doi: 10.1074/jbc.C111.229096. Epub 2011 Mar 3.

The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.

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1
Section Microbiology, Immunology, Glycobiology, Institute of Laboratory Medicine, Lund University, Sölvegatan 23, SE-223 62 Lund, Sweden.

Abstract

Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred- to thousand-fold higher affinity. Anginex also interacts with galectin-2, -7, -8N, and -9N but not with galectin-3, -4, or -9C.

PMID:
21372130
PMCID:
PMC3077580
DOI:
10.1074/jbc.C111.229096
[Indexed for MEDLINE]
Free PMC Article
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