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Nature. 1990 Feb 1;343(6257):437-41.

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.

Author information

1
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

Abstract

A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.

PMID:
2137203
DOI:
10.1038/343437a0
[Indexed for MEDLINE]

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