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Nature. 1990 Jan 25;343(6256):336-40.

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor.

Author information

1
Synergen Inc., Boulder, Colorado 80301.

Abstract

Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.

PMID:
2137200
DOI:
10.1038/343336a0
[Indexed for MEDLINE]

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