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Int J Stroke. 2011 Apr;6(2):136-43. doi: 10.1111/j.1747-4949.2010.00568.x. Epub 2011 Jan 10.

The changing face of neurosyphilis.

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Division of Neurology, Cleveland Clinic, Cleveland, OH 44016, USA.


The incidence of syphilis has increased over the past decade, particularly among HIV-positive patients, and the presenting clinical features have changed since the beginning of the HIV epidemic. The clinical manifestations of neurosyphilis are protean, and include acute stroke. In patients with HIV, the diagnosis and treatment of neurosyphilis is challenging. We review the clinical presentation, pathophysiology, and treatment of neurosyphilis, with emphasis on neurosyphilis in the HIV population, and neurosyphilis as a cause of acute stroke.

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