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Epilepsia. 2011 Mar;52(3):e7-11. doi: 10.1111/j.1528-1167.2011.02981.x. Epub 2011 Mar 3.

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway.

Author information

1
Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Abstract

The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition.

PMID:
21371020
PMCID:
PMC3076631
DOI:
10.1111/j.1528-1167.2011.02981.x
[Indexed for MEDLINE]
Free PMC Article

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