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Psychiatr Genet. 2011 Oct;21(5):229-39. doi: 10.1097/YPG.0b013e328345465e.

Association of androgen receptor gene, CAG and GGN repeat length polymorphism and impulsive-disinhibited personality traits in inmates: the role of short-long haplotype.

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1
University of Lleida, Province, Spain. aluja@pip.udl.cat

Abstract

OBJECTIVE:

This study analyses the association between impulsive-disinhibited personality traits and the androgen receptor CAG and GGN repeat polymorphisms in both inmates and control samples.

METHODS:

We used two samples: 153 inmates (mean age= 33.31 years; standard deviation: 8.6; range: 20-63) and 108 controls (mean age= 26.71 years; standard deviation: 9.68; range: 17-53). A disinhibited personality construct was measured using the following personality scales: Sensation Seeking, Aggression-Hostility, Psychoticism, Sensitivity to Reward, Novelty Seeking and Impulsivity. A factor analysis of the six scales provided a normalized z index that was taken as a measure of impulsive-disinhibited personality.

RESULTS:

Our data show that inmates carrying CAG short and GGN long haplotype group (short-long haplotype) obtained higher scores on all personality scales. Differences were found for the Impulsive Sensation-Seeking scale (age-adjusted multivariate analysis, P<0.016) and z index (P<0.036). When comparing extreme groups in the impulsive-disinhibited personality index (taking the 75th percentile as a cut-off), carriers of the short-long haplotype were more prevalent in the extreme high group (30 vs. 10%: unadjusted odds ratio=3.8; 95% confidence interval=1.5-9.8; age-adjusted odds ratio=4.4; 95% confidence interval=1.6-12; P<0.004).

CONCLUSION:

Our findings suggest that the androgen receptor CAG and GGN polymorphisms might influence impulsive-disinhibited personality traits.

PMID:
21368712
DOI:
10.1097/YPG.0b013e328345465e
[Indexed for MEDLINE]
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