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J Clin Microbiol. 2011 May;49(5):2027-30. doi: 10.1128/JCM.00084-11. Epub 2011 Mar 2.

Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid.

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1
Department of Medical Microbiology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, Netherlands. N.D.van_Burgel@LUMC.nl

Abstract

CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing Lyme neuroborreliosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.

PMID:
21367992
PMCID:
PMC3122636
DOI:
10.1128/JCM.00084-11
[Indexed for MEDLINE]
Free PMC Article
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