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J Virol. 2011 May;85(10):5232-6. doi: 10.1128/JVI.00093-11. Epub 2011 Mar 2.

Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.

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  • 1University Hospital Freiburg, Department of Medicine II, Hugstetter Str. 55, 79106 Freiburg, Germany.

Abstract

The impact of naïve-precursor frequency on human virus-specific CD8(+) T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a >10-fold difference in naïve-precursor frequencies across three HLA-A2-restricted hepatitis C virus (HCV)-specific epitopes. Importantly, the NS3(1406) epitope with the highest naïve-precursor frequency in healthy donors was also the most frequently targeted epitope in a large cohort of chronically HCV-infected patients, both ex vivo and after in vitro stimulation. These results indicate for the first time that immunodominance in a human viral infection is linked to naïve-precursor frequency.

PMID:
21367907
PMCID:
PMC3126217
DOI:
10.1128/JVI.00093-11
[PubMed - indexed for MEDLINE]
Free PMC Article
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