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J Virol. 2011 May;85(10):5197-201. doi: 10.1128/JVI.02692-10. Epub 2011 Mar 2.

Keratinocytes are cell targets of West Nile virus in vivo.

Author information

1
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.

Abstract

West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin 10. Inoculation of mice with WNV replicon particles resulted in high levels of replication in the skin, suggesting that keratinocytes are an initial target of WNV. In addition, primary keratinocytes produced infectious virus in vitro. In conclusion, keratinocytes are cell targets of WNV in vivo and may play an important role in pathogenesis.

PMID:
21367890
PMCID:
PMC3126165
DOI:
10.1128/JVI.02692-10
[Indexed for MEDLINE]
Free PMC Article

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