Abstract
Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models.
MeSH terms
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Animals
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Catalytic Domain / genetics
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Computational Biology* / methods
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Evolution, Molecular*
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Glycosylation
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Humans
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Insulin Receptor Substrate Proteins / chemistry
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Insulin Receptor Substrate Proteins / genetics*
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Insulin Receptor Substrate Proteins / metabolism
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Insulin Receptor Substrate Proteins / physiology
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Insulin Resistance / genetics
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Models, Biological
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Models, Molecular
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Models, Theoretical
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Multigene Family*
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Phylogeny
Substances
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Insulin Receptor Substrate Proteins