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Cell Death Dis. 2010 Jun 3;1:e48. doi: 10.1038/cddis.2010.27.

Bcl-2-regulated cell death signalling in the prevention of autoimmunity.

Author information

1
Division of Developmental Immunology, BIOCENTER, Medical University Innsbruck, Innsbruck, Austria.

Abstract

Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.

PMID:
21364654
PMCID:
PMC3032315
DOI:
10.1038/cddis.2010.27
[Indexed for MEDLINE]
Free PMC Article

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