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Cell Stem Cell. 2011 Mar 4;8(3):262-5. doi: 10.1016/j.stem.2011.02.012.

Phosphoryl-EZH-ion.

Author information

1
Department of Biomolecular Sciences and Biotechnology, University of Milan, 20133 Milan, Italy.

Abstract

Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular signals to specific epigenetic signatures.

PMID:
21362566
PMCID:
PMC3166223
DOI:
10.1016/j.stem.2011.02.012
[Indexed for MEDLINE]
Free PMC Article

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