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Cell Stem Cell. 2011 Mar 4;8(3):252-61. doi: 10.1016/j.stem.2011.02.014.

Biomimetic platforms for human stem cell research.

Author information

1
Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA. gv2131@columbia.edu

Abstract

Stem cells are central to developing new treatment options for tissue regeneration and constructing controllable models for biological research. Bioengineered cell culture environments that combine microenvironmental control with tissue-specific transport and signaling are critical tools in our efforts to study tissue development, regeneration, and disease under conditions that predict the human in vivo context. We propose that experimentation at the interfaces of biology, engineering, and medical sciences is critical for unlocking the full potential of stem cells. Here, we focus on the design and utilization of in vitro platforms that recapitulate the environments associated with tissue development, disease, and regeneration.

PMID:
21362565
PMCID:
PMC3048803
DOI:
10.1016/j.stem.2011.02.014
[Indexed for MEDLINE]
Free PMC Article

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