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Cell Stem Cell. 2011 Mar 4;8(3):242-4. doi: 10.1016/j.stem.2011.02.015.

Clever leukemic stem cells branch out.

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1
MRC Molecular Haematology Unit, Radcliffe Hospital, Oxford OX3 9DU, UK. paresh.vyas@imm.ox.ac.uk

Abstract

Individual tumors harbor heterogeneous populations of genetically distinct subclones. Two recent papers in Nature by Notta et al. (2011) and Anderson et al. (2011) reveal genetic heterogeneity in functional leukemic stem cells, which has important implications for how both cancer and normal stem cell populations may adapt to selective pressure.

PMID:
21362561
DOI:
10.1016/j.stem.2011.02.015
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