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Prev Sci. 2013 Apr;14(2):144-56. doi: 10.1007/s11121-011-0207-8.

Methods for synthesizing findings on moderation effects across multiple randomized trials.

Author information

  • 1University of Miami, Miller School of Medicine, Miami, FL, USA. chbrown@med.miami.edu

Abstract

This paper presents new methods for synthesizing results from subgroup and moderation analyses across different randomized trials. We demonstrate that such a synthesis generally results in additional power to detect significant moderation findings above what one would find in a single trial. Three general methods for conducting synthesis analyses are discussed, with two methods, integrative data analysis and parallel analyses, sharing a large advantage over traditional methods available in meta-analysis. We present a broad class of analytic models to examine moderation effects across trials that can be used to assess their overall effect and explain sources of heterogeneity, and present ways to disentangle differences across trials due to individual differences, contextual level differences, intervention, and trial design.

PMID:
21360061
PMCID:
PMC3135722
DOI:
10.1007/s11121-011-0207-8
[PubMed - indexed for MEDLINE]
Free PMC Article
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