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Mol Cells. 2011 Jun;31(6):491-6. doi: 10.1007/s10059-011-1004-8. Epub 2011 Feb 23.

The coded functions of noncoding RNAs for gene regulation.

Author information

1
Structural Biology Laboratory of Epigenetics, Department of Biological Sciences, Graduate School of Nanoscience and Technology (World Class University), KI Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.

Abstract

For eukaryotes, fine tuning of gene expression is necessary to coordinate complex genetic information. Recent studies have shown that noncoding RNAs (ncRNAs) play central roles in this process. For example, ncRNAs participate in multiple diverse functions such as mRNA degradation, epigenetic regulation and alternative splicing. The findings regarding this new player in gene regulation suggest that the mechanism of gene regulation is much more complicated and subtle than previously thought. In this review, new findings concerning the role of ncRNAs in gene regulation are discussed.

PMID:
21359682
PMCID:
PMC3887622
DOI:
10.1007/s10059-011-1004-8
[Indexed for MEDLINE]
Free PMC Article

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