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Mol Cells. 2011 May;31(5):423-9. doi: 10.1007/s10059-011-0256-7. Epub 2011 Feb 22.

Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence.

Author information

1
Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea.

Abstract

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.

PMID:
21359681
PMCID:
PMC3887607
DOI:
10.1007/s10059-011-0256-7
[Indexed for MEDLINE]
Free PMC Article

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