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Nat Rev Drug Discov. 2011 Mar;10(3):188-95. doi: 10.1038/nrd3368.

Impact of high-throughput screening in biomedical research.

Author information

1
Department of Sample Management Technologies, GlaxoSmithKline, Mail Stop UP 12-200, 1250S Collegeville Rd, Collegeville, Pennsylvania 19426, USA. ricardo.macarron@gsk.com

Abstract

High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.

PMID:
21358738
DOI:
10.1038/nrd3368
[Indexed for MEDLINE]

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