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Diabetes Care. 2011 Apr;34(4):994-9. doi: 10.2337/dc10-1593. Epub 2011 Feb 28.

Fasting indicators of insulin sensitivity: effects of ethnicity and pubertal status.

Author information

1
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. goran@usc.edu

Abstract

OBJECTIVE:

To examine the relationship of fasting indicators of insulin sensitivity with a more invasive measure of insulin sensitivity (frequently sampled intravenous glucose tolerance test [FSIVGTT]) and the effect of Tanner stage and ethnicity on that relationship.

RESEARCH DESIGN AND METHODS:

Data were analyzed from 149 overweight girls (97 Hispanic and 52 African American) who were either in the early stages of maturation defined by Tanner stages 1 or 2 (52 Hispanic and 18 African American) or in the later stages of maturation defined by Tanner stages 4 and 5 (45 Hispanic and 34 African American). Fasting indicators of insulin sensitivity (IS) included fasting insulin and glucose and the homeostasis model assessment of insulin resistance (HOMA-IR). IS was derived from an FSIVGTT with minimal modeling.

RESULTS:

In Tanner stages 1 and 2, all fasting indicators were significantly associated with IS: (fasting insulin: r = -0.67, P < 0.01; HOMA: r = -0.66, P < 0.01) with no significant influence of ethnicity on these relationships. In Tanner stages 4 and 5, however, all fasting indicators were associated with IS in African American girls (fasting insulin: r = -0.55, P < 0.01; HOMA: r = -0.47, P < 0.01), but none of the indicators were significantly associated with IS in Hispanic girls.

CONCLUSIONS:

Fasting indicators were reflective of IS for girls in Tanner stages 1 and 2, regardless of ethnicity and may provide a clinical measure of future risk for type 2 diabetes. In the latter stages of maturation, however, more invasive measures are warranted to adequately determine IS in clinical practice.

PMID:
21357795
PMCID:
PMC3064063
DOI:
10.2337/dc10-1593
[Indexed for MEDLINE]
Free PMC Article
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