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Cell Metab. 2011 Mar 2;13(3):233-4. doi: 10.1016/j.cmet.2011.02.006.

Glycogen synthase: an old enzyme with a new trick.

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1
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Phosphorylation of glycogen has been known for decades; however, the basic metabolic pathways responsible for this modification are unknown. In this issue, Tagliabracci et al. (2011) report the enzyme responsible for incorporating phosphate and the chemical nature of the phosphate linkage, providing a framework for expanding our understanding of a devastating form of epilepsy.

PMID:
21356510
DOI:
10.1016/j.cmet.2011.02.006
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