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Am J Pathol. 2011 Mar;178(3):946-55. doi: 10.1016/j.ajpath.2010.12.004.

Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases.

Author information

1
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1070, USA. baxq755@nenu.edu.cn

Abstract

Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to the receptor protein, is a unique posttranslational modification. Poly(ADP-ribose) polymerase-1 (PARP-1) is a well-characterized member of the PARP family. In this review, we provide a general update on molecular structure and structure-based activity of this enzyme. However, we mainly focus on the roles of PARP-1 in inflammatory diseases. Specifically, we discuss the signaling pathway context that PARP-1 is involved in to regulate the pathogenesis of inflammation. PARP-1 facilitates diverse inflammatory responses by promoting inflammation-relevant gene expression, such as cytokines, oxidation-reduction-related enzymes, and adhesion molecules. Excessive activation of PARP-1 induces mitochondria-associated cell death in injured tissues and constitutes another mechanism for exacerbating inflammation.

PMID:
21356345
PMCID:
PMC3069822
DOI:
10.1016/j.ajpath.2010.12.004
[Indexed for MEDLINE]
Free PMC Article
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